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The last 5 uploaded publications
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography
Albert H. Chan, Won‐Gil Lee, Krasimir A. Spasov, José A. Cisneros, Shalley N. Kudalkar, Zaritza O. Petrova, Amanda B. Buckingham, Karen S. Anderson, William L. Jorgensen (2017). Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proceedings of the National Academy of Sciences, 114(36), pp. 9725-9730, DOI: 10.1073/pnas.1711463114.
Article364 days agoDesign, Synthesis, and Protein Crystallography of Biaryltriazoles as Potent Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor
Pawel Dziedzic, José A. Cisneros, Michael J. Robertson, Alissa A. Hare, Nadia E. Danford, Richard H. G. Baxter, William L. Jorgensen (2015). Design, Synthesis, and Protein Crystallography of Biaryltriazoles as Potent Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor. Journal of the American Chemical Society, 137(8), pp. 2996-3003, DOI: 10.1021/ja512112j.
Article364 days agoCrystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design
Kathleen M. Frey, Mariela Bollini, Andrea C. Mislak, José A. Cisneros, Ricardo Gallardo‐Macias, William L. Jorgensen, Karen S. Anderson (2012). Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design. Journal of the American Chemical Society, 134(48), pp. 19501-19503, DOI: 10.1021/ja3092642.
Article364 days agoA Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors
José A. Cisneros, Michael J. Robertson, Margarita Valhondo, William L. Jorgensen (2016). A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. Journal of the American Chemical Society, 138(27), pp. 8630-8638, DOI: 10.1021/jacs.6b04910.
Article364 days agoSystematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules
José A. Cisneros, Michael J. Robertson, Brandon Q. Mercado, William L. Jorgensen (2016). Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules. ACS Medicinal Chemistry Letters, 8(1), pp. 124-127, DOI: 10.1021/acsmedchemlett.6b00451.
Article364 days ago