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Get Free AccessX-ray crystal structures at 2.9 Å resolution are reported for two complexes of catechol diethers with HIV-1 reverse transcriptase. The results help elucidate the structural origins of the extreme antiviral activity of the compounds. The possibility of halogen bonding between the inhibitors and Pro95 is addressed. Structural analysis reveals key interactions with conserved residues P95 and W229 of importance for design of inhibitors with high potency and favorable resistance profiles.
Kathleen M. Frey, Mariela Bollini, Andrea C. Mislak, José A. Cisneros, Ricardo Gallardo‐Macias, William L. Jorgensen, Karen S. Anderson (2012). Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design. Journal of the American Chemical Society, 134(48), pp. 19501-19503, DOI: 10.1021/ja3092642.
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Type
Article
Year
2012
Authors
7
Datasets
0
Total Files
0
Language
English
Journal
Journal of the American Chemical Society
DOI
10.1021/ja3092642
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