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The last 5 uploaded publications
Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics
Brandon J. Bloomer, Sean N. Natoli, Marc Garcia‐Borràs, J.H. Pereira, Derek B. Hu, Paul D. Adams, K. N. Houk, Douglas S. Clark, John F Hartwig (2023). Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics. , 6(1), DOI: https://doi.org/10.1038/s41929-022-00899-9.
Article68 days agoComplete integration of carbene-transfer chemistry into biosynthesis
Jing Huang, Andrew F. G. Quest, Pablo Cruz‐Morales, Kai Deng, J.H. Pereira, Devon Van Cura, Ramu Kakumanu, Edward E. K. Baidoo, Qingyun Dan, Yan Chen, Christopher J. Petzold, Trent R. Northen, Paul D. Adams, Douglas S. Clark, Emily P. Balskus, John F Hartwig, Aindrila Mukhopadhyay, Jay D. Keasling (2023). Complete integration of carbene-transfer chemistry into biosynthesis. , 617(7960), DOI: https://doi.org/10.1038/s41586-023-06027-2.
Article68 days agoA polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids
Qingyun Dan, Yan Chiu, Namil Lee, J.H. Pereira, Behzad Rad, Xixi Zhao, Kai Deng, Yinghui Rong, Chunjun Zhan, Yan Chen, Seokjung Cheong, Chenyi Li, Jennifer Gin, Andria V. Rodrigues, Trent R. Northen, Tyler W. H. Backman, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Jay D Keasling (2025). A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids. , 8(2), DOI: https://doi.org/10.1038/s41929-025-01299-5.
Article26 days agoA highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone
Zilong Wang, Seokjung Cheong, J.H. Pereira, Wenyi Hu, Yuquan Guo, Andy DeGiovanni, Guangxu Lan, Jinho Kim, Robert W. Haushalter, Taek Soon Lee, Paul D. Adams, Jay D Keasling (2025). A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone. , 16(1), DOI: https://doi.org/10.1038/s41467-025-65946-y.
Article26 days agoEnzymology and Structural Basis of Glycosyltransferases Involved in Saponin C28 Carboxylic Acid <i>O</i> - <scp>d</scp> -Fucosylation
Graham A. Hudson, J.H. Pereira, Peter H. Winegar, David Fitzgerald, Andy DeGiovanni, Xixi Zhao, M. Astolfi, James Reed, Amr El‐Demerdash, Martin Rejzek, Shingo Kikuchi, Anne Osbourn, Henrik Vibe Scheller, Paul D. Adams, Jay D Keasling (2025). Enzymology and Structural Basis of Glycosyltransferases Involved in Saponin C28 Carboxylic Acid <i>O</i> - <scp>d</scp> -Fucosylation. , 5(12), DOI: https://doi.org/10.1021/jacsau.5c00907.
Article26 days ago