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The last 5 uploaded publications
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
Dongwei Kang, Francesc X. Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, De Clercq Erik, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan (2020). Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. , 63(3), DOI: https://doi.org/10.1021/acs.jmedchem.9b01769.
Article55 days agoDiscovery of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP
Dongwei Kang, Xiao Ding, Gaochan Wu, Zhipeng Huo, Zhongxia Zhou, Tong Zhao, Da Feng, Zhao Wang, Ye Tian, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2017). Discovery of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. , 8(11), DOI: https://doi.org/10.1021/acsmedchemlett.7b00361.
Article55 days agoExploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs
Dongwei Kang, Da Feng, Tiziana Ginex, Jinmi Zou, Fenju Wei, Tong Zhao, Boshi Huang, Yanying Sun, Samuel Desta, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2019). Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs. , 10(5), DOI: https://doi.org/10.1016/j.apsb.2019.08.013.
Article55 days agoIdentification of Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, F. Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, Jian Zhang, De Clercq Erik, Christophe Pannecouque, Chin Ho Chen, Kuo‐Hsiung Lee, N. Arul Murugan, Thomas A. Steitz, Peng Zhan, Xinyong Liu (2019). Identification of Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. , 62(3), DOI: https://doi.org/10.1021/acs.jmedchem.8b01656.
Article55 days agoDiscovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing
Tong Zhao, Qing Meng, Dongwei Kang, Jianbo Ji, De Clercq Erik, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2019). Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing. , 182, DOI: https://doi.org/10.1016/j.ejmech.2019.111619.
Article55 days ago