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The last 5 uploaded publications
Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7
Matteo Boretto, Maarten H. Geurts, Shashank Gandhi, Ma Ziliang, Nadzeya Staliarova, Martina Celotti, Sang-Ho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers, Matteo Boretto, Maarten H. Geurts, Shashank Gandhi, Ma Ziliang, Nadzeya Staliarova, Martina Celotti, Sang-Ho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers (2024). Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. , 121(12), DOI: https://doi.org/10.1073/pnas.2309902121.
Article12 days agoEpidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7
Matteo Boretto, Maarten H. Geurts, Shashank Gandhi, Ma Ziliang, Nadzeya Staliarova, Martina Celotti, Sang-Ho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers, Matteo Boretto, Maarten H. Geurts, Shashank Gandhi, Ma Ziliang, Nadzeya Staliarova, Martina Celotti, Sang-Ho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers (2024). Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. , 121(12), DOI: https://doi.org/10.1073/pnas.2309902121.
Article12 days agoLong-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
Amanda Andersson-Rolf, Kelvin Groot, Jeroen Korving, Harry Begthel, Maaike A.J. Hanegraaf, Michael VanInsberghe, Fredrik Salmén, Stieneke van den Brink, Carmen López-Iglesias, Peter J. Peters, Daniel Krueger, Joep Beumer, Maarten H. Geurts, Anna Alemany, Helmuth Gehart, Françoise Carlotti, Eelco J.P. de Koning, Susana M. Chuva de Sousa Lopes, Alexander van Oudenaarden, Johan H. van Es, Hans Clevers (2024). Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages. , 187(26), DOI: https://doi.org/10.1016/j.cell.2024.10.044.
Article12 days agoTuft cells act as regenerative stem cells in the human intestine
Lulu Huang, Jochem H. Bernink, Amir Giladi, Daniel Krueger, Gijs J. F. van Son, Maarten H. Geurts, Georg Busslinger, Lin Lin, Maurice M.J.M. Zandvliet, Peter J. Peters, Carmen López‐Iglesias, Christianne J. Buskens, Willem A. Bemelman, Harry Begthel, Hans Clevers (2024). Tuft cells act as regenerative stem cells in the human intestine. , DOI: https://doi.org/10.1101/2024.03.17.585165.
Preprint12 days agoRecapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Tomohiro Mizutani, Matteo Boretto, Sang-Ho Lim, Jarno Drost, Diego Montiel González, Rurika Oka, Maarten H. Geurts, Harry Begthel, Jeroen Korving, Johan H. van Es, Ruben van Boxtel, Hans Clevers, Tomohiro Mizutani, Matteo Boretto, Sang-Ho Lim, Jarno Drost, Diego Montiel González, Rurika Oka, Maarten H. Geurts, Harry Begthel, Jeroen Korving, Johan H. van Es, Ruben van Boxtel, Hans Clevers (2024). Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids. , 5(12), DOI: https://doi.org/10.1038/s43018-024-00841-x.
Article12 days ago