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The last 5 uploaded publications
The role of itaconate in host defense and inflammation
Christian G. Peace, Luke O'neill (2022). The role of itaconate in host defense and inflammation. Journal of Clinical Investigation, 132(2), DOI: 10.1172/jci148548.
Article277 days agoItaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick, Rui Santalla Méndez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke O'neill (2022). Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metabolism, 34(3), pp. 487-501.e8, DOI: 10.1016/j.cmet.2022.02.002.
Article277 days agoMacrophage fumarate hydratase restrains mtRNA-mediated interferon production
Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado‐Carrancio, Alva M. Casey, Hiran A. Prag, Ana S.H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alex von Kriegsheim, Michael P. Murphy, Caroline A. Jefferies, Christian Frezza, Luke O'neill (2023). Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature, 615(7952), pp. 490-498, DOI: 10.1038/s41586-023-05720-6.
Article277 days agoDimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhán Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke O'neill (2023). Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nature Communications, 14(1), DOI: 10.1038/s41467-023-39174-1.
Article277 days agoNLRP3, the inflammasome and COVID-19 infection
Maureen Yin, Laura Marrone, Christian G. Peace, Luke O'neill (2023). NLRP3, the inflammasome and COVID-19 infection. QJM, 116(7), pp. 502-507, DOI: 10.1093/qjmed/hcad011.
Article277 days ago