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The last 5 uploaded publications
Lactate controls cancer stemness and plasticity through epigenetic regulation
Nguyen T.B. Nguyen, Sira Gevers, Rutger N.U. Kok, Lotte M Burgering, Hannah K. Neikes, Ninouk Akkerman, Max A. Betjes, Marlies C. Ludikhuize, Can Gulersonmez, Edwin C.A. Stigter, Yvonne Vercoulen, Jarno Drost, Hans Clevers, Michiel Vermeulen, Jeroen S. van Zon, Sander J. Tans, Boudewijn Burgering, Maria J. Rodríguez Colman (2025). Lactate controls cancer stemness and plasticity through epigenetic regulation. , 37(4), DOI: https://doi.org/10.1016/j.cmet.2025.01.002.
Article68 days agoEpithelial tension controls intestinal cell extrusion
Daniel Krueger, Willem Kasper Spoelstra, Dirk Jan Mastebroek, Rutger N.U. Kok, Sanlan Wu, Mikhail Nikolaev, Marie Bannier-Hélaouët, Nikolche Gjorevski, Matthias P. Lütolf, Johan H. van Es, Jeroen S. van Zon, Sander J. Tans, Hans Clevers (2025). Epithelial tension controls intestinal cell extrusion. , 389(6764), DOI: https://doi.org/10.1126/science.adr8753.
Article68 days agoLoss of Paneth cell contact starts a WNT differentiation timer in intestinal crypts
Jeroen S. van Zon, Rutger N.U. Kok, Xuan Zheng, Willem Kasper Spoelstra, Tinka V M Clement, Yorick van de Grift, Hans Clevers, Renée van Amerongen, Sander J. Tans (2024). Loss of Paneth cell contact starts a WNT differentiation timer in intestinal crypts. , DOI: https://doi.org/10.21203/rs.3.rs-5452594/v1.
Preprint68 days agoFast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing
Benedetta Artegiani, Delilah Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, Susana M. Chuva de Sousa Lopes, Jeroen S. van Zon, Sander J. Tans, Hans Clevers (2020). Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing. , 22(3), DOI: https://doi.org/10.1038/s41556-020-0472-5.
Article49 days agoFast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing
Benedetta Artegiani, Delilah Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, Susana M. Chuva de Sousa Lopes, Jeroen S. van Zon, Sander J. Tans, Hans Clevers (2020). Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing. , DOI: https://doi.org/10.1101/2020.01.15.907766.
Preprint49 days ago