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The last 5 uploaded publications
Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity
Boshi Huang, Dongwei Kang, Ye Tian, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity. , 97(1), DOI: https://doi.org/10.1111/cbdd.13760.
Article29 days agoIn situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
Dongwei Kang, Da Feng, Lanlan Jing, Yanying Sun, Fenju Wei, Xiangyi Jiang, Gaochan Wu, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. , 193, DOI: https://doi.org/10.1016/j.ejmech.2020.112237.
Article29 days agoStructure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
Daxiong Li, Chunsheng Zhang, Wei Ding, Siming Huang, Le Yu, Nan Lu, Wenkai Pan, Yiming Li, De Clercq Erik, Christophe Pannecouque, Hongbing Zhang, Yueping Wang, Yan‐Ping He, Fen‐Er Chen (2020). Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. , 32(3), DOI: https://doi.org/10.1016/j.cclet.2020.09.035.
Article29 days agoPharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
Ya-Li Sang, Christophe Pannecouque, De Clercq Erik, Chunlin Zhuang, Fen‐Er Chen (2020). Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. , 96, DOI: https://doi.org/10.1016/j.bioorg.2020.103595.
Article29 days agoExploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties
Xiangyi Jiang, Boshi Huang, Fisayo A. Olotu, Jing Li, Dongwei Kang, Zhao Wang, De Clercq Erik, Mahmoud E. S. Soliman, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties. , 213, DOI: https://doi.org/10.1016/j.ejmech.2020.113051.
Article29 days ago