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The last 5 uploaded publications
ChemInform Abstract: Synthesis and anti‐HIV Activity Evaluation of Novel 2,4‐Disubstituted 7‐Methyl‐1,1,3‐trioxo‐2,4‐dihydro‐pyrazolo[4,5‐e][1,2]thiadiazines.
Xinyong Liu, Renzhang Yan, Yan Wang, Peng Zhan, De Clercq Erik, Christophe Pannecouque, Myriam Witvrouw, Marı́a Teresa Molina, Salvador Vega (2008). ChemInform Abstract: Synthesis and anti‐HIV Activity Evaluation of Novel 2,4‐Disubstituted 7‐Methyl‐1,1,3‐trioxo‐2,4‐dihydro‐pyrazolo[4,5‐e][1,2]thiadiazines.. , 39(32), DOI: https://doi.org/10.1002/chin.200832169.
Article88 days agoDesign, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles
Xiangkai Ji, Xiangyi Jiang, X. T. Huang, Heng Gao, Zhen Gao, Ping Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu (2025). Design, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles. , DOI: https://doi.org/10.2139/ssrn.5348172.
Preprint89 days agoFurther Exploring the Tolerant Region Ii: Identification of 2,4,5-Trisubstituted Pyrimidines as Hiv-1 Reverse Transcriptase Allosteric Inhibitors with Desirable Antiviral Activities and Reduced Cytotoxicity
Zhenzhen Zhou, Zheng Lin, Wenbo Jiang, Wenbo Zhang, Fabao Zhao, Zhening Liang, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu (2025). Further Exploring the Tolerant Region Ii: Identification of 2,4,5-Trisubstituted Pyrimidines as Hiv-1 Reverse Transcriptase Allosteric Inhibitors with Desirable Antiviral Activities and Reduced Cytotoxicity. , DOI: https://doi.org/10.2139/ssrn.5288498.
Preprint89 days agoDiscovery of novel diarypyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant region I within NNRTI binding pocket
Xiangkai Ji, Xiangyi Jiang, Zhen Gao, Heng Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Shujing Xu, Xinyong Liu (2025). Discovery of novel diarypyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant region I within NNRTI binding pocket. , 295, DOI: https://doi.org/10.1016/j.ejmech.2025.117787.
Article89 days agoDiscovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization
Dongwei Kang, Xinyong Liu, Peng Zhan, Lanlan Jing, Gaochan Wu, Fabao Zhao, Xiangyi Jiang, Na Liu, Da Feng, Yanying Sun, Tao Zhang, De Clercq Erik, Christophe Pannecouque (2024). Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization. , 277, DOI: https://doi.org/10.1016/j.ejmech.2024.116772.
Article89 days ago