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The last 5 uploaded publications
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark Hughes, Alan D. Irvine, Román Fischer, Luke O'neill (2020). The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metabolism, 32(3), pp. 468-478.e7, DOI: 10.1016/j.cmet.2020.07.016.
Article253 days agoCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona, Richard G. Carroll, Eva M. Pålsson‐McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George A. Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel J. O’Connell, Ramnik J. Xavier, Karsten Hokamp, Luke O'neill, Annie M. Curtis (2018). Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences, 115(36), DOI: 10.1073/pnas.1800431115.
Article253 days agoPharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
Stefano Angiari, Marah C. Runtsch, Caroline E. Sutton, Eva M. Pålsson‐McDermott, Beth Kelly, Nisha Rana, Harry Kane, Gina Papadopoulou, Erika L. Pearce, Kingston H. G. Mills, Luke O'neill (2019). Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity. Cell Metabolism, 31(2), pp. 391-405.e8, DOI: 10.1016/j.cmet.2019.10.015.
Article253 days agoItaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick, Rui Santalla Méndez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke O'neill (2022). Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metabolism, 34(3), pp. 487-501.e8, DOI: 10.1016/j.cmet.2022.02.002.
Article253 days agoAn unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Richard G. Carroll, Zbigniew Zasłona, Silvia Galván-Peña, Emma Koppe, Daniel C. Sévin, Stefano Angiari, Martha Triantafilou, Kathy Triantafilou, Louise K. Modis, Luke O'neill (2018). An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry, 293(15), pp. 5509-5521, DOI: 10.1074/jbc.ra118.001921.
Article253 days ago