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The last 5 uploaded publications
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
Dongwei Kang, Da Feng, Lanlan Jing, Yanying Sun, Fenju Wei, Xiangyi Jiang, Gaochan Wu, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. , 193, DOI: https://doi.org/10.1016/j.ejmech.2020.112237.
Article43 days agoStructure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs
Dongwei Kang, Yanying Sun, N. Arul Murugan, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). Structure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs. , 6(8), DOI: https://doi.org/10.1021/acsinfecdis.0c00327.
Article43 days agoDiscovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
Dongwei Kang, Francesc X. Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, De Clercq Erik, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan (2020). Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. , 63(3), DOI: https://doi.org/10.1021/acs.jmedchem.9b01769.
Article43 days ago2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies
Dongwei Kang, Francesc X. Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, De Clercq Erik, Christophe Pannecouque, Eddy Arnold, Peng Zhan, Xinyong Liu (2021). 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. , 64(7), DOI: https://doi.org/10.1021/acs.jmedchem.1c00268.
Article43 days agoStructure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei, De Clercq Erik, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. , 63(9), DOI: https://doi.org/10.1021/acs.jmedchem.0c00117.
Article43 days ago