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Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score
Rui P. Moreno, Andrew Rhodes, Otávio T. Ranzani, Jorge I. Salluh, Joana Berger‐Estilita, Craig M. Coopersmith, Nicole P. Juffermans, John G. Laffey, Matti Reinikainen, Ary Serpa Neto, Miguel Tavares, Jean-François Timsit, M.D.P. Arias Lopez, Nish Arulkumaran, Elie Azoulay, Dipayan Chaudhuri, Dylan W. de Lange, Jan J. De Waele, Claúdia C. dos Santos, Bin Du, Sharon Einav, Ricard Ferrer, Tomoko Fujii, Hayley B. Gershengorn, Rashan Haniffa, Mohd Shahnaz Hasan, Steve Hollenberg, Mariachiara Ippolito, Christian Jung, М. Yu. Кirov, Inès Lakbar, Jeffrey Lipman, Vincent X. Liu, Suzana Margareth Lobo, Greg S. Martin, Philipp Metnitz, Sheila Nainan Myatra, Simon Oczkowski, José Artur Paiva, Fathima Paruk, Pirkka T. Pekkarinen, David Pilcher, Lise Piquilloud, Anssi Pölkki, Halle C. Prescott, Annika Reintam Blaser, Ederlon Rezende, Chiara Robba, Bram Rochwerg, Edward J. Schenck, Cornelius Sendagire, Moses Siaw-Frimpong, Andrew J. Simpkin, Márcio Soares, Charlotte Summers, Wojciech Szczeklik, Jukka Takala, Jean Louis Vincent, J. Wendon, Fernando G. Zampieri, Manu Shankar‐Hari, Mervyn Singer (2025). Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score. , 8(10), DOI: https://doi.org/10.1001/jamanetworkopen.2025.45040.
Article18 days agoDevelopment and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Otávio T. Ranzani, Mervyn Singer, Jorge I. Salluh, Manu Shankar‐Hari, David Pilcher, Joana Berger-Estilita, Craig M. Coopersmith, Nicole P. Juffermans, John G. Laffey, Matti Reinikainen, Ary Serpa Neto, Miguel Tavares, Jean-François Timsit, María del Pilar Arias López, Nish Arulkumaran, Diptesh Aryal, Elie Azoulay, Jack Gallifant, Dipayan Chaudhuri, Dylan W. de Lange, Jan J. De Waele, Claúdia C. dos Santos, Bin Du, Sharon Einav, Teresa Engelbrecht, Fathima Fazla, Ricard Ferrer, Stefano Finazzi, Tomoko Fujii, Hayley B. Gershengorn, J Greene, Rashan Haniffa, Sicheng Hao, Mohd Shahnaz Hasan, Steve Hollenberg, Mariachiara Ippolito, Christian Jung, М. Yu. Кirov, Shinichi Kobari, Inès Lakbar, Jeffrey Lipman, Vincent X. Liu, Xiaoli Liu, Suzana M. Lobo, Demetrio Magatti, Greg S. Martin, Barbara Metnitz, Philipp Metnitz, Sheila Nainan Myatra, Simon Oczkowski, José Artur Paiva, Fathima Paruk, Pirkka T. Pekkarinen, Lise Piquilloud, Anssi Pölkki, Hallie C. Prescott, Annika Reintam Blaser, Ederlon Rezende, Chiara Robba, Bram Rochwerg, Stéphane Ruckly, Rasoul Samei, Edward J. Schenck, Paul Secombe, Cornelius Sendagire, Moses Siaw-Frimpong, Andrew J. Simpkin, Márcio Soares, Charlotte Summers, Wojciech Szczeklik, Jukka Takala, Shiro Tanaka, Giovanni Tricella, Jean Louis Vincent, J. Wendon, Fernando G. Zampieri, Andrew Rhodes, Rui P. Moreno (2025). Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score. , 334(23), DOI: https://doi.org/10.1001/jama.2025.20516.
Article18 days agoFrom ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU
Anthony Gordon, Narges Alipanah, Lieuwe D. J. Bos, José Dianti, Janet Dı́az, Simon Finfer, Tomoko Fujii, Evangelos J. Giamarellos‐Bourboulis, Ewan C. Goligher, Michelle N. Gong, Eleni Karakike, Vincent X. Liu, Nuttha Lumlertgul, John C. Marshall, David Menon, Nuala J. Meyer, Elizabeth Munroe, Sheila Nainan Myatra, Marlies Ostermann, Hallie C. Prescott, Adrienne G. Randolph, Edward J. Schenck, Christopher W. Seymour, Manu Shankar‐Hari, Mervyn Singer, Marry R. Smit, Aiko Tanaka, Fabio Silvio Taccone, Bruce Thompson, Lisa K. Torres, Tom van der Poll, Jean Louis Vincent, Carolyn S. Calfee (2024). From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU. , 210(2), DOI: https://doi.org/10.1164/rccm.202311-2086so.
Article18 days agoReframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies
Manu Shankar‐Hari, Thierry Calandra, Miguel P. Soares, Michael Bauer, W. Joost Wiersinga, Hallie C. Prescott, Julian C. Knight, J. Kenneth Baillie, Lieuwe D. J. Bos, Lennie Derde, Simon Finfer, Richard S. Hotchkiss, John C. Marshall, Peter Openshaw, Christopher W. Seymour, Fabienne Venet, Jean Louis Vincent, Christophe Le Tourneau, Anke H. Maitland‐van der Zee, Iain B. McInnes, Tom van der Poll (2024). Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies. , 12(4), DOI: https://doi.org/10.1016/s2213-2600(23)00468-x.
Article18 days agoEfficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)
Tobias Welte, R. Phillip Dellinger, Henning Ebelt, Miguel Ferrer, Steven M. Opal, Mervyn Singer, Jean Louis Vincent, Karl Werdan, Ignacio Martín‐Loeches, Jordi Almirall, Antonio Artigas, Ignacio Ayestarán, Sebastian Nuding, Ricard Ferrer, Gonzalo Sirgo Rodríguez, Manu Shankar‐Hari, Francisco Álvarez-Lerma, Reimer Rießen, Josep-María Sirvent, Stefan Kluge, Kai Zacharowski, Juan Bonastre Mora, Harald Lapp, Gabriele Wöbker, Ute Achtzehn, David Brealey, Axel Kempa, Miguel Sánchez García, Jörg Brederlau, Matthias Kochanek, Henrik Reschreiter, Matt P. Wise, Bernd H. Belohradsky, Iris Bobenhausen, Benjamin Dälken, Patrick Dubovy, Patrick Langohr, Monika Mayer, Jörg Schüttrumpf, Andrea Wartenberg‐Demand, Ulrike Wippermann, Daniele Wolf, Antoní Torres (2018). Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study). , 44(4), DOI: https://doi.org/10.1007/s00134-018-5143-7.
Article18 days ago