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The last 5 uploaded publications
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties
Xiangyi Jiang, Boshi Huang, Fisayo A. Olotu, Jing Li, Dongwei Kang, Zhao Wang, De Clercq Erik, Mahmoud E. S. Soliman, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties. , 213, DOI: https://doi.org/10.1016/j.ejmech.2020.113051.
Article42 days agoDiscovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7
Songkai Sun, Boshi Huang, Zhuo Li, Zhao Wang, Lin Sun, Ping Gao, Dongwei Kang, Chin‐Ho Chen, Kuo‐Hsiung Lee, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7. , 30(16), DOI: https://doi.org/10.1016/j.bmcl.2020.127287.
Article42 days agoDesign, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity
Boshi Huang, Dongwei Kang, Ye Tian, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity. , 97(1), DOI: https://doi.org/10.1111/cbdd.13760.
Article42 days agoSynthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against <scp>HIV</scp> and Influenza A/H1N1 Infections
Dongwei Kang, Zengjun Fang, Boshi Huang, Lingzi Zhang, Huiqing Liu, Christophe Pannecouque, Lieve Naesens, De Clercq Erik, Peng Zhan, Xinyong Liu (2015). Synthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against <scp>HIV</scp> and Influenza A/H1N1 Infections. , 86(4), DOI: https://doi.org/10.1111/cbdd.12520.
Article42 days agoDiscovery of small molecular inhibitors targeting HIV-1 gp120–CD4 interaction drived from BMS-378806
Tao Liu, Boshi Huang, Peng Zhan, De Clercq Erik, Xinyong Liu (2014). Discovery of small molecular inhibitors targeting HIV-1 gp120–CD4 interaction drived from BMS-378806. , 86, DOI: https://doi.org/10.1016/j.ejmech.2014.09.012.
Article42 days ago