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The last 5 uploaded publications
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article249 days agoPyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel, Mario A. Lauterbach, Frederick J. Sheedy, Laura E. Gleeson, Mirjam W.M. van den Bosch, Susan R. Quinn, Raquel Domingo-Fernandéz, Daniel Johnston, Jian‐kang Jiang, William J. Israelsen, Joseph Keane, Craig J. Thomas, Clary B. Clish, Matthew G. Vander Heiden, Ramnik J. Xavier, Luke O'neill (2015). Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell Metabolism, 21(1), pp. 65-80, DOI: 10.1016/j.cmet.2014.12.005.
Article249 days agoGlutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih‐Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, J.W.M. van der Meer, Colin Logie, Luke O'neill, Charles A. Dinarello, Niels P. Riksen, Reinout van Crevel, Clary B. Clish, Richard A. Notebaart, Leo A. B. Joosten, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea (2016). Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. Cell Metabolism, 24(6), pp. 807-819, DOI: 10.1016/j.cmet.2016.10.008.
Article249 days agoβ-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
Lee D. Roberts, Pontus Boström, John O’Sullivan, Robert T. Schinzel, Gregory D. Lewis, Andrè Dejam, Youn‐Kyoung Lee, Melinda J. Palma, Sondra Calhoun, Anastasia Georgiadi, Ming‐Huei Chen, Ramachandran S. Vasan, Martin G. Larson, Claude Bouchard, Tuomo Rankinen, Amanda L. Souza, Clary B. Clish, Thomas J. Wang, Jennifer L. Estall, Alexander A. Soukas, Chad A. Cowan, Bruce M. Spiegelman, Robert E. Gerszten (2014). β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metabolism, 19(1), pp. 96-108, DOI: 10.1016/j.cmet.2013.12.003.
Article227 days agoThe HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers
Mark A. Sarzynski, Treva Rice, Jean‐Pierre Després, Louis Pérusse, Angelo Tremblay, Philip R. Stanforth, André Tchernof, Jacob L. Barber, Francesco Falciani, Clary B. Clish, Jeremy Robbins, Sujoy Ghosh, Robert E. Gerszten, Arthur S. Leon, James S. Skinner, D. C. Rao, Claude Bouchard (2022). The HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers. Medicine & Science in Sports & Exercise, 54(5S), pp. S1-S43, DOI: 10.1249/mss.0000000000002859.
Article227 days ago