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The last 5 uploaded publications
Complete integration of carbene-transfer chemistry into biosynthesis
Jing Huang, Andrew F. G. Quest, Pablo Cruz‐Morales, Kai Deng, J.H. Pereira, Devon Van Cura, Ramu Kakumanu, Edward E. K. Baidoo, Qingyun Dan, Yan Chen, Christopher J. Petzold, Trent R. Northen, Paul D. Adams, Douglas S. Clark, Emily P. Balskus, John F Hartwig, Aindrila Mukhopadhyay, Jay D. Keasling (2023). Complete integration of carbene-transfer chemistry into biosynthesis. , 617(7960), DOI: https://doi.org/10.1038/s41586-023-06027-2.
Article67 days agoHeterologous Gene Expression of <i>N</i>-Terminally Truncated Variants of LipPks1 Suggests a Functionally Critical Structural Motif in the <i>N</i>-terminus of Modular Polyketide Synthase
Satoshi Yuzawa, Constance B. Bailey, Tatsuya Fujii, Renee Jocic, Jesus F. Barajas, Veronica T. Benites, Edward E. K. Baidoo, Yan Chen, Christopher J. Petzold, Leonard Katz, Jay D Keasling (2017). Heterologous Gene Expression of <i>N</i>-Terminally Truncated Variants of LipPks1 Suggests a Functionally Critical Structural Motif in the <i>N</i>-terminus of Modular Polyketide Synthase. , 12(11), DOI: https://doi.org/10.1021/acschembio.7b00714.
Article25 days agoA polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids
Qingyun Dan, Yan Chiu, Namil Lee, J.H. Pereira, Behzad Rad, Xixi Zhao, Kai Deng, Yinghui Rong, Chunjun Zhan, Yan Chen, Seokjung Cheong, Chenyi Li, Jennifer Gin, Andria V. Rodrigues, Trent R. Northen, Tyler W. H. Backman, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Jay D Keasling (2025). A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids. , 8(2), DOI: https://doi.org/10.1038/s41929-025-01299-5.
Article25 days agoFeedstock-efficient conversion through hydrogen and formate-driven metabolism in Escherichia coli
Robert L. Bertrand, Justin Panich, Aidan E. Cowan, Jacob B. Roberts, Lesley J. Rodriguez, Lesley J. Rodriguez, Juliana Artier, Edward E. K. Baidoo, Yan Chen, Christopher J. Petzold, Graham A. Hudson, Patrick M. Shih, Steven W. Singer, Jay D Keasling (2025). Feedstock-efficient conversion through hydrogen and formate-driven metabolism in Escherichia coli. , 93, DOI: https://doi.org/10.1016/j.ymben.2025.10.003.
Article25 days agoEngineering Polyketide Stereocenters with Ketoreductase Domain Exchanges
Leah S. Keiser, Panarai Primrose Gatenil, Yun Zhu, Kai Deng, Lucas Waldburger, Jennifer Gin, Yan Chen, Edward E. K. Baidoo, Christopher J. Petzold, Nathan Lanclos, Trent R. Northen, Elias Englund, Jay D Keasling (2025). Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges. , 147(46), DOI: https://doi.org/10.1021/jacs.5c06736.
Article25 days ago