Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W. Gribble, Grace Q. Alba, Merrill Ayres, Timothy J. Carlson, Ada Chen, Xiaoqi Chen, Robert Cho, Richard Connors, Michael DeGraffenreid, Jeffrey Deignan, Jason Duquette, Pingchen Fan, Benjamin Fisher, Jiasheng Fu, Justin Huard, Jacob A. Kaizerman, Kathleen S. Keegan, Cong Li, Kexue Li, Yunxiao Li, Lingming Liang, Wen Liu, Sarah Lively, Mei-Chu Lo, Ji Ma, Dustin L. McMinn, Jeffrey T. Mihalic, Kriti Modi, Rachel Ngo, Kanaka Pattabiraman, Derek E. Piper, Christophe Quéva, Mark L. Ragains, Julia Suchomel, Steve Thibault, Nigel P.C. Walker, Xiaodong Wang, Zhong Lin Wang, Malgorzata Wanska, Paul M. Wehn, Margaret F. Weidner, Alex J. Zhang, Xiaoning Zhao, Alexander Kamb, Dineli Wickramasinghe, Kang Dai, Lawrence R. McGee, Julio C. Medina (2014). Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3. , 57(8), DOI: https://doi.org/10.1021/jm500118j.
