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The last 5 uploaded publications
Structure-Guided Identification of DNMT3B Inhibitors
Ana S. Newton, John C. Faver, Goran Micevic, Viswanathan Muthusamy, Shalley N. Kudalkar, Nicole Bertoletti, Karen S. Anderson, Marcus Bosenberg, William L. Jorgensen (2020). Structure-Guided Identification of DNMT3B Inhibitors. ACS Medicinal Chemistry Letters, 11(5), pp. 971-976, DOI: 10.1021/acsmedchemlett.0c00011.
Article406 days agoComputationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
D. J. A. Cole, M. Janecek, Jamie E. Stokes, Maxim Rossmann, John C. Faver, Grahame J. McKenzie, Ashok R. Venkitaraman, Marko Hyvönen, David R. Spring, David J. Huggins, William L. Jorgensen (2017). Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction. Chemical Communications, 53(67), pp. 9372-9375, DOI: 10.1039/c7cc05379g.
Article406 days agoIndoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant
Ana S. Newton, Maria-Elena Liosi, Sean P. Henry, Luca Deiana, John C. Faver, S.G. Krimmer, D.E. Puleo, Joseph Schlessinger, William L. Jorgensen (2021). Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant. Tetrahedron Letters, 77, pp. 153248-153248, DOI: 10.1016/j.tetlet.2021.153248.
Article406 days ago