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The last 5 uploaded publications
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties
Xiangyi Jiang, Boshi Huang, Fisayo A. Olotu, Jing Li, Dongwei Kang, Zhao Wang, De Clercq Erik, Mahmoud E. S. Soliman, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties. , 213, DOI: https://doi.org/10.1016/j.ejmech.2020.113051.
Article38 days agoDiscovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
Dongwei Kang, Francesc X. Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, De Clercq Erik, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan (2020). Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. , 63(3), DOI: https://doi.org/10.1021/acs.jmedchem.9b01769.
Article38 days agoTargeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility
Zhao Wang, Dongwei Kang, Da Feng, Srinivasulu Cherukupalli, Xiangyi Jiang, Zhipeng Fu, De Clercq Erik, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. , 206, DOI: https://doi.org/10.1016/j.ejmech.2020.112811.
Article38 days ago2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies
Dongwei Kang, Francesc X. Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, De Clercq Erik, Christophe Pannecouque, Eddy Arnold, Peng Zhan, Xinyong Liu (2021). 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. , 64(7), DOI: https://doi.org/10.1021/acs.jmedchem.1c00268.
Article38 days agoDiscovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7
Songkai Sun, Boshi Huang, Zhuo Li, Zhao Wang, Lin Sun, Ping Gao, Dongwei Kang, Chin‐Ho Chen, Kuo‐Hsiung Lee, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7. , 30(16), DOI: https://doi.org/10.1016/j.bmcl.2020.127287.
Article38 days ago