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The last 5 uploaded publications
Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity
Sarah Doyle, Luke O'neill (2006). Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity. Biochemical Pharmacology, 72(9), pp. 1102-1113, DOI: 10.1016/j.bcp.2006.07.010.
Article269 days agoSuppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
Ashley Mansell, Rosealee Smith, Sarah Doyle, Pearl Gray, Jennifer E Fenner, Peter J. Crack, Sandra E. Nicholson, Douglas J. Hilton, Luke O'neill, Paul J. Hertzog (2006). Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nature Immunology, 7(2), pp. 148-155, DOI: 10.1038/ni1299.
Article269 days agoTherapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer
Luke O'neill, Clare Bryant, Sarah Doyle (2009). Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer. Pharmacological Reviews, 61(2), pp. 177-197, DOI: 10.1124/pr.109.001073.
Article269 days agoNLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
Sarah Doyle, Matthew Campbell, Ema Ozaki, Robert G. Salomon, Andrés Mori, Paul F. Kenna, G. Jane Farrar, Anna‐Sophia Kiang, Marian M. Humphries, Ed C. Lavelle, Luke O'neill, Joe G. Hollyfield, Peter Humphries (2012). NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nature Medicine, 18(5), pp. 791-798, DOI: 10.1038/nm.2717.
Article269 days agoIL-10 Inhibits miR-155 Induction by Toll-like Receptors
Claire E. McCoy, Frederick J. Sheedy, Joseph E. Qualls, Sarah Doyle, Susan R. Quinn, Peter J. Murray, Luke O'neill (2010). IL-10 Inhibits miR-155 Induction by Toll-like Receptors. Journal of Biological Chemistry, 285(27), pp. 20492-20498, DOI: 10.1074/jbc.m110.102111.
Article269 days ago