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The last 5 uploaded publications
Maximizing microbial bioproduction from sustainable carbon sources using iterative systems engineering
Thomas Eng, Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer Gin, Hemant Choudhary, Edward E. K. Baidoo, Jian-Hua Chen, Axel Ekman, Ramu Kakumanu, Yuzhong Liu, Alex Codik, Carolyn A. Larabell, John M. Gladden, Blake A. Simmons, Jay D Keasling, Christopher J. Petzold, Aindrila Mukhopadhyay (2023). Maximizing microbial bioproduction from sustainable carbon sources using iterative systems engineering. , 42(9), DOI: https://doi.org/10.1016/j.celrep.2023.113087.
Article30 days agoFast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli
Aidan E. Cowan, Mason Hillers, Vittorio Rainaldi, Florent Collas, Hemant Choudhary, Basem S. Zakaria, Gregory Guerra, David N. Carruthers, Maxwell Grabovac, Jennifer Gin, Bridgie Cawthon, Yan Chen, Emine Akyüz Turumtay, Edward E. K. Baidoo, Christopher J. Petzold, Adam M. Feist, Sara Tejedor-Sanz, Frank Kensy, Blake A. Simmons, Jay D Keasling, Nico J. Claassens (2025). Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli. , 16(1), DOI: https://doi.org/10.1038/s41467-025-61001-y.
Article30 days agoA polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids
Qingyun Dan, Yan Chiu, Namil Lee, J.H. Pereira, Behzad Rad, Xixi Zhao, Kai Deng, Yinghui Rong, Chunjun Zhan, Yan Chen, Seokjung Cheong, Chenyi Li, Jennifer Gin, Andria V. Rodrigues, Trent R. Northen, Tyler W. H. Backman, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Jay D Keasling (2025). A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids. , 8(2), DOI: https://doi.org/10.1038/s41929-025-01299-5.
Article30 days agoEngineering Polyketide Stereocenters with Ketoreductase Domain Exchanges
Leah S. Keiser, Panarai Primrose Gatenil, Yun Zhu, Kai Deng, Lucas Waldburger, Jennifer Gin, Yan Chen, Edward E. K. Baidoo, Christopher J. Petzold, Nathan Lanclos, Trent R. Northen, Elias Englund, Jay D Keasling (2025). Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges. , 147(46), DOI: https://doi.org/10.1021/jacs.5c06736.
Article30 days agoEngineering controllable alteration of malonyl-CoA levels to enhance polyketide production
Sarah H. Klass, Mia Wesselkamper, Aidan E. Cowan, Namil Lee, Nathan Lanclos, Seokjung Cheong, Zilong Wang, Yan Chen, Jennifer Gin, Christopher J. Petzold, Jay D Keasling (2025). Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production. , 21(8), DOI: https://doi.org/10.1038/s41589-025-01911-6.
Article30 days ago