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The last 5 uploaded publications
Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles
Xiangkai Ji, Xiangyi Jiang, Zhen Gao, Heng Gao, X. T. Huang, Fabao Zhao, De Clercq Erik, Zhao Wang, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu (2025). Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles. , 68(19), DOI: https://doi.org/10.1021/acs.jmedchem.5c01695.
Article88 days agoCorrection to “Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles”
Xiangkai Ji, Xiangyi Jiang, Zhen Gao, Heng Gao, X. T. Huang, Fabao Zhao, De Clercq Erik, Zhao Wang, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu (2025). Correction to “Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles”. , 68(21), DOI: https://doi.org/10.1021/acs.jmedchem.5c02923.
Article88 days agoDesign, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles
Xiangkai Ji, Xiangyi Jiang, X. T. Huang, Heng Gao, Zhen Gao, Ping Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu (2025). Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles. , 164, DOI: https://doi.org/10.1016/j.bioorg.2025.108924.
Article88 days agoDesign, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles
Xiangkai Ji, Xiangyi Jiang, X. T. Huang, Heng Gao, Zhen Gao, Ping Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu (2025). Design, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles. , DOI: https://doi.org/10.2139/ssrn.5348172.
Preprint88 days agoStructure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles
Xiangkai Ji, Xiangyi Jiang, Heng Gao, Zhen Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu (2025). Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles. , 68(21), DOI: https://doi.org/10.1021/acs.jmedchem.5c02211.
Article88 days ago