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The last 5 uploaded publications
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
Dongwei Kang, Da Feng, Lanlan Jing, Yanying Sun, Fenju Wei, Xiangyi Jiang, Gaochan Wu, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. , 193, DOI: https://doi.org/10.1016/j.ejmech.2020.112237.
Article43 days agoDiscovery of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP
Dongwei Kang, Xiao Ding, Gaochan Wu, Zhipeng Huo, Zhongxia Zhou, Tong Zhao, Da Feng, Zhao Wang, Ye Tian, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2017). Discovery of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. , 8(11), DOI: https://doi.org/10.1021/acsmedchemlett.7b00361.
Article43 days agoStructure-Based Optimization of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants
Dongwei Kang, Zengjun Fang, Boshi Huang, Xueyi Lu, Heng Zhang, Haoran Xu, Zhipeng Huo, Zhongxia Zhou, Yu Zhao, Qing Meng, Gaochan Wu, Xiao Ding, Ye Tian, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2017). Structure-Based Optimization of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. , 60(10), DOI: https://doi.org/10.1021/acs.jmedchem.7b00332.
Article43 days agoDiscovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization
Dongwei Kang, Xinyong Liu, Peng Zhan, Lanlan Jing, Gaochan Wu, Fabao Zhao, Xiangyi Jiang, Na Liu, Da Feng, Yanying Sun, Tao Zhang, De Clercq Erik, Christophe Pannecouque (2024). Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization. , 277, DOI: https://doi.org/10.1016/j.ejmech.2024.116772.
Article43 days agoTargeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus
Zhongxia Zhou, Tao Liu, Gaochan Wu, Dongwei Kang, Zhipeng Fu, Zhao Wang, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2019). Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus. , 17(12), DOI: https://doi.org/10.1039/c9ob00032a.
Article43 days ago