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The last 5 uploaded publications
A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium
Anindita Mukerjee, Pinar Iyidogan, Alejandro Castellanos-González, José A. Cisneros, Daniel J. Czyzyk, Amalendu P. Ranjan, William L. Jorgensen, A. Clinton White, Jamboor K. Vishwanatha, Karen S. Anderson (2015). A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium. Bioorganic & Medicinal Chemistry Letters, 25(10), pp. 2065-2067, DOI: 10.1016/j.bmcl.2015.03.091.
Article360 days agoNovel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening
Victor G. Ruiz, Daniel J. Czyzyk, Margarita Valhondo, William L. Jorgensen, Karen S. Anderson (2019). Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening. Bioorganic & Medicinal Chemistry Letters, 29(11), pp. 1413-1418, DOI: 10.1016/j.bmcl.2019.03.022.
Article360 days agoStructure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors
Daniel J. Czyzyk, Margarita Valhondo, Luca Deiana, Julian Tirado‐Rives, William L. Jorgensen, Karen S. Anderson (2019). Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. European Journal of Medicinal Chemistry, 183, pp. 111673-111673, DOI: 10.1016/j.ejmech.2019.111673.
Article360 days agoUnderstanding the structural basis of species selective, stereospecific inhibition for <i>Cryptosporidium</i> and human thymidylate synthase
Daniel J. Czyzyk, Margarita Valhondo, William L. Jorgensen, Karen S. Anderson (2019). Understanding the structural basis of species selective, stereospecific inhibition for <i>Cryptosporidium</i> and human thymidylate synthase. FEBS Letters, 593(15), pp. 2069-2078, DOI: 10.1002/1873-3468.13474.
Article360 days agoProdrug Nanotherapy Demonstrate In Vivo Anticryptosporidial Efficacy in a Mouse Model of Chronic Cryptosporidium Infection
Amalendu P. Ranjan, Daniel J. Czyzyk, Griselle Martinez-Traverso, Aygül Sadıqova, Margarita Valhondo, Deborah A. Schaefer, Krasimir A. Spasov, William L. Jorgensen, Jamboor K. Vishwanatha, Michael W. Riggs, Alejandro Castellanos-González, Karen S. Anderson (2024). Prodrug Nanotherapy Demonstrate In Vivo Anticryptosporidial Efficacy in a Mouse Model of Chronic Cryptosporidium Infection. RSC Pharmaceutics, DOI: 10.1039/d4pm00093e.
Article360 days ago