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The last 5 uploaded publications
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis
Sayaka Inokuchi‐Shimizu, Eek Joong Park, Yoon Seok Roh, Ling Yang, Bi Zhang, Jingyi Song, Shuang Liang, Michael Pimienta, Koji Taniguchi, Xuefeng Wu, Kinji Asahina, William Lagakos, Mason R. Mackey, Akira Shizuo, Mark H. Ellisman, Dorothy D. Sears, Jerrold M. Olefsky, Michael Karin, David A. Brenner, Ekihiro Seki (2014). TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Journal of Clinical Investigation, 124(8), pp. 3566-3578, DOI: 10.1172/jci74068.
Article419 days agoChronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
Helena Shaked, Lorne J. Hofseth, Alena Chumanevich, Alexander A. Chumanevich, Jin Wang, Yinsheng Wang, Koji Taniguchi, Mónica Gumà, Steve Shenouda, Hans Clevers, Curtis C. Harris, Michael Karin (2012). Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. , 109(35), DOI: https://doi.org/10.1073/pnas.1211509109.
Article68 days agomAChR4 suppresses liver disease via GAP-induced antimicrobial immunity
Cristina Llorente, Fernanda Raya Tonetti, Ryan Bruellman, Rocío Brea, Núria Pell, Phillipp Hartmann, Luca Maccioni, Hui Han, Noemí Cabré, Junlai Liu, Álvaro Eguileor, Marcos F. Fondevila, Abraham S. Meijnikman, Cynthia L. Hsu, Ameera Alghafri, Rongrong Zhou, Bei Gao, Yi Duan, Peng Zhang, Mark A. Febbraio, Koji Taniguchi, Rodney D. Newberry, Derrick E. Fouts, David A. Brenner, Peter Stärkel, Michael Karin, Bernd Schnabl (2025). mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity. , 646(8083), DOI: https://doi.org/10.1038/s41586-025-09395-z.
Article68 days agoA YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
Toshiro Moroishi, Hyun Woo Park, Bao‐Dong Qin, Qian Chen, Zhipeng Meng, Steven W. Plouffe, Koji Taniguchi, Fa‐Xing Yu, Michael Karin, Duojia Pan, Kun‐Liang Guan (2015). A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. , 29(12), DOI: https://doi.org/10.1101/gad.262816.115.
Article68 days agoTargeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling
Elsa Sánchez‐López, Efrat Flashner-Abramson, Shabnam Shalapour, Zhenyu Zhong, Koji Taniguchi, Alexander Levitzki, Michael Karin (2015). Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. , 35(20), DOI: https://doi.org/10.1038/onc.2015.326.
Article68 days ago