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The last 5 uploaded publications
Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W. Gribble, Grace Q. Alba, Merrill Ayres, Timothy J. Carlson, Ada Chen, Xiaoqi Chen, Robert Cho, Richard Connors, Michael DeGraffenreid, Jeffrey Deignan, Jason Duquette, Pingchen Fan, Benjamin Fisher, Jiasheng Fu, Justin Huard, Jacob A. Kaizerman, Kathleen S. Keegan, Cong Li, Kexue Li, Yunxiao Li, Lingming Liang, Wen Liu, Sarah Lively, Mei-Chu Lo, Ji Ma, Dustin L. McMinn, Jeffrey T. Mihalic, Kriti Modi, Rachel Ngo, Kanaka Pattabiraman, Derek E. Piper, Christophe Quéva, Mark L. Ragains, Julia Suchomel, Steve Thibault, Nigel P.C. Walker, Xiaodong Wang, Zhong Lin Wang, Malgorzata Wanska, Paul M. Wehn, Margaret F. Weidner, Alex J. Zhang, Xiaoning Zhao, Alexander Kamb, Dineli Wickramasinghe, Kang Dai, Lawrence R. McGee, Julio C. Medina (2014). Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3. , 57(8), DOI: https://doi.org/10.1021/jm500118j.
Article267 days agoOptimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors
Dustin L. McMinn, Yosup Rew, Athena Sudom, Seb Caille, Michael DeGraffenreid, Xiaodong He, Randall W. Hungate, Ben Jiang, Juan C. Jaén, Lisa D. Julian, Jacob A. Kaizerman, Perry M. Novak, Daqing Sun, Hua Tu, Stefania Ursu, Nigel P.C. Walker, Xuelei Yan, Qiuping Ye, Zhong Lin Wang, Jay P. Powers (2009). Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors. , 19(5), DOI: https://doi.org/10.1016/j.bmcl.2009.01.026.
Article267 days agoDiscovery and optimization of piperidyl benzamide derivatives as a novel class of 11β-HSD1 inhibitors
Yosup Rew, Dustin L. McMinn, Zhong Lin Wang, Xiaodong He, Randall W. Hungate, Juan C. Jaén, Athena Sudom, Daqing Sun, Hua Tu, Stefania Ursu, Elisia Villemure, Nigel P.C. Walker, Xuelei Yan, Qiuping Ye, Jay P. Powers (2009). Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11β-HSD1 inhibitors. , 19(6), DOI: https://doi.org/10.1016/j.bmcl.2009.01.058.
Article267 days agoDiscovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model<sup>▽</sup>
Lisa D. Julian, Zhong Lin Wang, Tracy Bostick, Seb Caille, Rebekah Choi, Michael DeGraffenreid, Yongmei Di, Xiaodong He, Randall W. Hungate, Juan C. Jaén, Jinsong Liu, Mario Monshouwer, Dustin L. McMinn, Yosup Rew, Athena Sudom, Daqing Sun, Hua Tu, Stefania Ursu, Nigel P.C. Walker, Xuelei Yan, Qiuping Ye, Jay P. Powers (2008). Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model<sup>▽</sup>. , 51(13), DOI: https://doi.org/10.1021/jm800310g.
Article267 days agoThe synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors
Xuelei Yan, Zhong Lin Wang, Athena Sudom, Mario Cardozo, Michael DeGraffenreid, Yongmei Di, Pingchen Fan, Xiaodong He, Juan C. Jaén, Marc Labelle, Jinsong Liu, Ji Ma, Dustin L. McMinn, Shichang Miao, Daqing Sun, Liang Tang, Hua Tu, Stefania Ursu, Nigel P.C. Walker, Qiuping Ye, Jay P. Powers (2010). The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors. , 20(23), DOI: https://doi.org/10.1016/j.bmcl.2010.09.097.
Article263 days ago