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The last 5 uploaded publications
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
Dongwei Kang, Da Feng, Lanlan Jing, Yanying Sun, Fenju Wei, Xiangyi Jiang, Gaochan Wu, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. , 193, DOI: https://doi.org/10.1016/j.ejmech.2020.112237.
Article33 days agoExploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties
Xiangyi Jiang, Boshi Huang, Fisayo A. Olotu, Jing Li, Dongwei Kang, Zhao Wang, De Clercq Erik, Mahmoud E. S. Soliman, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties. , 213, DOI: https://doi.org/10.1016/j.ejmech.2020.113051.
Article33 days agoStructure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs
Dongwei Kang, Yanying Sun, N. Arul Murugan, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu (2020). Structure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs. , 6(8), DOI: https://doi.org/10.1021/acsinfecdis.0c00327.
Article33 days agoTargeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility
Zhao Wang, Dongwei Kang, Da Feng, Srinivasulu Cherukupalli, Xiangyi Jiang, Zhipeng Fu, De Clercq Erik, Christophe Pannecouque, Xinyong Liu, Peng Zhan (2020). Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. , 206, DOI: https://doi.org/10.1016/j.ejmech.2020.112811.
Article33 days agoDesign, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors
Xujie Zhang, Lin Sun, Megan E. Meuser, Waleed A. Zalloum, Shujing Xu, Tianguang Huang, Srinivasulu Cherukupalli, Xiangyi Jiang, Xiao Ding, Yucen Tao, Dongwei Kang, De Clercq Erik, Christophe Pannecouque, Alexej Dick, Simon Cocklin, Xinyong Liu, Peng Zhan (2021). Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors. , 226, DOI: https://doi.org/10.1016/j.ejmech.2021.113848.
Article33 days ago