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The last 5 uploaded publications
Lactate controls cancer stemness and plasticity through epigenetic regulation
Nguyen T.B. Nguyen, Sira Gevers, Rutger N.U. Kok, Lotte M Burgering, Hannah K. Neikes, Ninouk Akkerman, Max A. Betjes, Marlies C. Ludikhuize, Can Gulersonmez, Edwin C.A. Stigter, Yvonne Vercoulen, Jarno Drost, Hans Clevers, Michiel Vermeulen, Jeroen S. van Zon, Sander J. Tans, Boudewijn Burgering, Maria J. Rodríguez Colman (2025). Lactate controls cancer stemness and plasticity through epigenetic regulation. , 37(4), DOI: https://doi.org/10.1016/j.cmet.2025.01.002.
Article64 days agoIntestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients
Julian R. Buissant des Amorie, Max A. Betjes, Jochem H. Bernink, Joris H. Hageman, Veerle Geurts, Harry Begthel, Dimitrios Laskaris, Maria C. Heinz, Ingrid Jordens, Tiba Vinck, Ronja M. Houtekamer, Ingrid Verlaan-Klink, Sascha R. Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J. Tans, Jeroen S. van Zon, Hugo J.G. Snippert (2025). Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients. , 16(1), DOI: https://doi.org/10.1038/s41467-025-61878-9.
Article64 days agoMature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia
Julian R. Buissant des Amorie, Max A. Betjes, Jochem H. Bernink, Joris H. Hageman, Maria C. Heinz, Ingrid Jordens, Tiba Vinck, Ronja M. Houtekamer, Ingrid Verlaan-Klink, Sascha R. Brunner, Dimitrios Laskaris, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Jeroen S. van Zon, Sander J. Tans, Hugo J.G. Snippert (2024). Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia. , DOI: https://doi.org/10.1101/2024.11.28.625899.
Preprint64 days agoOrganoid cell fate dynamics in space and time
Xuan Zheng, Max A. Betjes, Pascal Ender, Yvonne J. Goos, Guizela Huelsz‐Prince, Hans Clevers, Jeroen S. van Zon, Sander J. Tans (2023). Organoid cell fate dynamics in space and time. , 9(33), DOI: https://doi.org/10.1126/sciadv.add6480.
Article64 days agoFollowing cell type transitions in space and time by combining live-cell tracking and endpoint cell identity in intestinal organoids
Xuan Zheng, Max A. Betjes, Yvonne J. Goos, Guizela Huelsz‐Prince, Hans Clevers, Jeroen S. van Zon, Sander J. Tans (2022). Following cell type transitions in space and time by combining live-cell tracking and endpoint cell identity in intestinal organoids. , DOI: https://doi.org/10.1101/2022.06.27.497728.
Preprint56 days ago