(Raw Data Set) Green synthesis, chemical characterization of gold nanoparticles decorated on biodegradable arabic gum modified magnetic nanoparticles for the treatment of leukemia

Abstract

In the current years, conjugated bio-nanomaterials involving magnetic core are interested as promising platform in new generation biological composites. In this regard, we described a novel Au NPs supported Arabic gum (AG) modified magnetic Fe3O4 nanoparticles as a novel anticancer agent (Fe3O4@AG/Au). The post-synthetically modified biogenic material was analyzed in details over a number of physicochemical methods like, Fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), elemental mapping, X-ray diffraction (XRD) and inductively coupled plasma-optical emission spectroscopy (ICP-OES). In the oncological part of the recent study, the treated cells with Fe3O4@AG/Au were assessed by MTT assay for 48 h about the cytotoxicity and anti-luekemia properties on normal (HUVEC) and luekemia cell lines i.e. MOLT-3, TALL-104, J.RT3-T3.5, 32D-FLT3-ITD and Human HL-60/vcr. The viability of malignant luekemia cell lines reduced dose-dependently in the presence of Fe3O4@AG/Au. The IC50 of Fe3O4@AG/Au were 248, 157, 156, 243, and 198 mu g/mL against MOLT-3, TALL-104, J.RT3-T3.5, 32D-FLT3-ITD and Human HL-60/vcr cell lines, respectively.