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gem-Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF3SiMe3-NaI System

Abstract

Difluorocyclopropanation of alkenyl trifluoroborates using TMSCF3-NaI system was reported for the first time. The developed method allowed preparation of monocyclic, spiro- and fused-bicyclic gem-difluorocyclopropanes bearing additional functional groups. The preparation of potassium (2,2-difluorocyclopropyl)trifluoroborates was achieved in up to 90 % yield on a multigram scale.

article Article
date_range 2020
language English
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Featured Keywords

Cyclopropane
Trifluoroborate
Organofluorine compounds
Ruppert-Prakash reagent
Difluorocarbene
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