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Get Free AccessThe frequency of VLEs followed by a large trial is vanishingly small, and where they occur they do not appear to be a reliable marker for a benefit that is reproducible and directly actionable. An empirical rule using a VLE in a randomised controlled trial as a marker that further trials are unnecessary would be neither practical nor useful. Caution should be taken when interpreting small studies with very large treatment effects.
Myura Nagendran, Tiago Pereira, Grace Kiew, Douglas G. Altman, Mahiben Maruthappu, John P A Ioannidis, Peter McCulloch (2016). Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment. , 355, DOI: https://doi.org/10.1136/bmj.i5432.
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Type
Article
Year
2016
Authors
7
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1136/bmj.i5432
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