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Get Free AccessABSTRACT Objective Higher thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Method Structural T 1 -weighted brain magnetic resonance imaging (MRI) scans from 2,649 OCD patients and 2,774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were preregistered ( https://osf.io/73dvy ) and adjusted for age, sex and intracranial volume. Results Unmedicated pediatric OCD patients (< 12 years) had larger lateral ( d = 0.46), pulvinar ( d = 0.33), ventral ( d = 0.35) and whole thalamus ( d = 0.40) volumes at unadjusted p -values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume ( d = -0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Conclusion Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul Arnold, Srinivas Balachander, Nerisa Banaj, Núria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sónia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean‐Paul Fouché, Rachael Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Fern Jaspers‐Fayer, Norbert Kathmann, C. Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lázaro, Chiang‐Shan R. Li, Christine Löchner, Rachel Marsh, Ignacio Martínez‐Zalacaín, David Mataix‐Cols, José M. Menchón, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O’Neill, Ana E. Ortiz, Jose Ángel Pariente, John Piacentini, Maria Picó‐Pérez, Federica Piras, Fabrizio Piras, Christopher Pittenger, Y.C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Nuno Sousa, Gianfranco Spalletta, Emily Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Anders Lillevik Thorsen, David F. Tolin, Ysbrand D. van der Werf, Hein J. F. van Marle, Guido van Wingen, Daniela Vecchio, Ganesan Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je‐Yeon Yun, Qing Zhao, Tonya White, Paul M. Thompson, Dan Joseph Stein (2021). The thalamus and its subnuclei: a gateway to obsessive-compulsive disorder. , DOI: https://doi.org/10.1101/2021.09.06.21262530.
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Type
Preprint
Year
2021
Authors
98
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1101/2021.09.06.21262530
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