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  5. The impact of irritant challenge on the skin barrier and myeloid-resident immune cells in women who are postmenopausal is modulated by hormone replacement therapy

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Article
en
2024

The impact of irritant challenge on the skin barrier and myeloid-resident immune cells in women who are postmenopausal is modulated by hormone replacement therapy

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0 Files

en
2024
Vol 191 (5)
Vol. 191
DOI: 10.1093/bjd/ljae226

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Christopher Em Griffiths
Christopher Em Griffiths

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Orsolya Kiss
Rajia Bahri
Rachel Watson
+7 more

Abstract

Individuals receiving HRT displayed enhanced skin barrier response to SLS challenge with thicker filaggrin and increased K10+ epidermal cell layers. Following challenge, HRT users exhibited elevated LC, inflammatory DC and macrophage counts in the dermis. These may render skin both more prone to inflammation and more capable of resolving it, while also promoting skin repair.

How to cite this publication

Orsolya Kiss, Rajia Bahri, Rachel Watson, C P R Chike, A.K. Langton, Victoria Newton, Mike Bell, Christopher Em Griffiths, Silvia Bulfone‐Paus, Suzanne M. Pilkington (2024). The impact of irritant challenge on the skin barrier and myeloid-resident immune cells in women who are postmenopausal is modulated by hormone replacement therapy. , 191(5), DOI: https://doi.org/10.1093/bjd/ljae226.

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Publication Details

Type

Article

Year

2024

Authors

10

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.1093/bjd/ljae226

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