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  5. Reversal of Aging‐Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein‐Protein Interfaces

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Article
en
2018

Reversal of Aging‐Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein‐Protein Interfaces

0 Datasets

0 Files

en
2018
Vol 7 (15)
Vol. 7
DOI: 10.1161/jaha.118.008926

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Emelia Benjamin
Emelia Benjamin

Institution not specified

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Christopher Nicholson
Kuldeep Singh
Robert J. Saphirstein
+81 more

Abstract

We conclude that decoy peptides targeted to vascular smooth muscle cytoskeletal protein-protein interfaces and microbubble packaged can decrease aortic stiffness ex vivo. Our results provide proof of concept at the ex vivo level that decoy peptides targeted to cytoskeletal protein-protein interfaces may lead to substantive dynamic modulation of aortic stiffness.

How to cite this publication

Christopher Nicholson, Kuldeep Singh, Robert J. Saphirstein, Yuan Gao, Qian Li, Joanna Chiu, Paul C. Leavis, Germaine C. Verwoert, Gary F. Mitchell, Tyrone M. Porter, Kathleen G. Morgan, Kirill V. Tarasov, Aaron Isaacs, Albert V. Smith, Yasmin Yasmin, Ernst Rietzschel, Toshiko Tanaka, Yongmei Liu, Afshin Parsa, Samer S. Najjar, Kevin M. O’Shaughnessy, Sigurður Sigurðsson, Marc De Buyzere, Martin G. Larson, Mark P.S. Sie, Jeanette S. Andrews, Wendy S. Post, Francesco Mattace‐Raso, Carmel M. McEniery, Guðný Eiríksdóttir, Patrick Segers, Ramachandran S. Vasan, Marie Josee E. van Rijn, Timothy D. Howard, Patrick F. McArdle, Abbas Dehghan, Elizabeth S. Jewell, Stephen Newhouse, Sofie Bekaert, Naomi M. Hamburg, Anne B. Newman, Albert Hofman, Angelo Scuteri, Dirk De Bacquer, M. Arfan Ikram, Bruce M. Psaty, Christian Fuchsberger, Matthias Olden, Louise V. Wain, Paul Elliott, Nicholas L. Smith, Janine F. Felix, Jeanette Erdmann, Joseph A. Vita, Kim Sutton‐Tyrrell, Eric J.G. Sijbrands, Serena Sanna, Lenore J. Launer, Tim De Meyer, Andrew D. Johnson, Anna FC Schut, David M. Herrington, Fernando Rivadeneira, Manuela Uda, Ian B. Wilkinson, Thor Aspelund, Thierry Gillebert, Luc Van Bortel, Emelia Benjamin, Ben A. Oostra, Jingzhong Ding, Quince Gibson, André G. Uitterlinden, Gonçalo R. Abecasis, John R. Cockcroft, Vilmundur Guðnason, Guy De Backer, Luigi Ferrucci, Tamara B. Harris, Alan R. Shuldiner, Cornelia M. van Duijn, Daniel Levy, Edward G. Lakatta, Jacqueline C.M. Witteman (2018). Reversal of Aging‐Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein‐Protein Interfaces. , 7(15), DOI: https://doi.org/10.1161/jaha.118.008926.

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Publication Details

Type

Article

Year

2018

Authors

84

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.1161/jaha.118.008926

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