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Get Free AccessPineal serotonin N -acetyltransferase (arylalkylamine N -acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that coordinates daily and seasonal physiology in some mammals. Complementary DNA encoding ovine AA-NAT was cloned. The abundance of AA-NAT messenger RNA (mRNA) during the day was high in the ovine pineal gland and somewhat lower in retina. AA-NAT mRNA was found unexpectedly in the pituitary gland and in some brain regions. The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases.
Steven L. Coon, Patrick H. Roseboom, Rubén Baler, Joan L. Weller, M.A.A. Namboodiri, Eugene V Koonin, David C. Klein (1995). Pineal Serotonin <i>N</i> -Acetyltransferase: Expression Cloning and Molecular Analysis. , 270(5242), DOI: https://doi.org/10.1126/science.270.5242.1681.
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Type
Article
Year
1995
Authors
7
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1126/science.270.5242.1681
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