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Get Free AccessAbstract UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF‐TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF‐ TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
Sean Harrop, Phillip Nguyen, David J. Byrne, Clarissa Wilson, Georgina L. Ryland, Tamia Nguyen, Mary Ann Anderson, Seong Lin Khaw, Michelle Martin, Ing Soo Tiong, Elaine Sanij, Piers Blombery (2023). Persistence of <i>UBTF</i> tandem duplications in remission in acute myeloid leukaemia. , 4(4), DOI: https://doi.org/10.1002/jha2.808.
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Type
Article
Year
2023
Authors
12
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/jha2.808
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