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Get Free AccessPrevious findings on the capacity of Hibiscus sabdariffa (HS) polyphenols to ameliorate metabolic disturbances justify the necessity of studies oriented to find the potential metabolites responsible for such an effect. The present study examined the intestinal epithelial membrane permeability of polyphenols present in a phenolic-enriched Hibiscus sabdariffa extract (PEHS), free and encapsulated, using the Caco-2 cell line. Additionally, selected polyphenols (quercetin, quercetin-3-glucoside, quercetin-3-glucuronide, and N-feruloyltyramine) were also studied in the same absorption model. The powerful analytical platform used ultra-high-performance liquid chromatography coupled with ultra-high-resolution quadrupole time-of-flight mass spectrometry (UHPLC-ESI-UHR-Qq-TOF-MS), and enabled the characterization of seven new compounds in PEHS. In the permeation study, only a few compounds were able to cross the cell monolayer and the permeability was lower when the extract was in an encapsulated form. Pure compounds showed a moderate absorption in all cases. Nevertheless, these preliminary results may need further research to understand the complete absorption mechanism of Hibiscus polyphenols.
Isabel Borrás‐Linares, María Herranz‐López, Enrique Barrajón‐Catalán, David Arraéz-Román, Isabel González‐Álvarez, Marival Bermejo, Alberto Fernandez Gutierrez, Vicente Micol, Antonio Segura‐Carretero (2015). Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS. , 16(8), DOI: https://doi.org/10.3390/ijms160818396.
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Type
Article
Year
2015
Authors
9
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.3390/ijms160818396
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