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  5. PEG–Lipid–PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs

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Article
en
2024

PEG–Lipid–PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs

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0 Files

en
2024
Vol 16 (2)
Vol. 16
DOI: 10.3390/pharmaceutics16020187

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Ulrich Sigmar Schubert
Ulrich Sigmar Schubert

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Jana Ismail
Lea C. Klepsch
Philipp Dahlke
+11 more

Abstract

Hybrid nanoparticles (HNPs) were designed by combining a PLGA core with a lipid shell that incorporated PEG-Lipid conjugates with various functionalities (-RGD, -cRGD, -NH2, and -COOH) to create targeted drug delivery systems. Loaded with a neutral lipid orange dye, the HNPs were extensively characterized using various techniques and investigated for their uptake in human monocyte-derived macrophages (MDMs) using FC and CLSM. Moreover, the best-performing HNPs (i.e., HNP-COOH and HNP-RGD as well as HNP-RGD/COOH mixed) were loaded with the anti-inflammatory drug BRP-201 and prepared in two size ranges (dH ~140 nm and dH ~250 nm). The HNPs were examined further for their stability, degradation, MDM uptake, and drug delivery efficiency by studying the inhibition of 5-lipoxygenase (5-LOX) product formation, whereby HNP-COOH and HNP-RGD both exhibited superior uptake, and the HNP-COOH/RGD (2:1) displayed the highest inhibition.

How to cite this publication

Jana Ismail, Lea C. Klepsch, Philipp Dahlke, Antje Vollrath, David Pretzel, Paul M. Jordan, Kourosh Rezaei, Natalie E. Göppert, Steffi Stumpf, Baerbel Beringer-Siemers, Ivo Nischang, Stephanie Hoeppener, Oliver Werz, Ulrich Sigmar Schubert (2024). PEG–Lipid–PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs. , 16(2), DOI: https://doi.org/10.3390/pharmaceutics16020187.

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Publication Details

Type

Article

Year

2024

Authors

14

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.3390/pharmaceutics16020187

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