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Get Free AccessVascular endothelial growth factor (VEGF) antagonists have been investigated as a potential treatment for psoriasis, but there have been reports of VEGF antagonists triggering and/or exacerbating pre-existing psoriasis. We present the case of a 61-year old-man with exacerbation of pre-existing psoriasis after treatment with sorafenib, a small molecule inhibitor of the tyrosine kinase domain of the VEGF receptor, and we review the literature for other published cases of sorafenib-induced or sorafenib-exacerbated psoriasis. Clinicians, including both dermatologists and oncologists, should be aware of this potential side-effect of sorafenib in addition to the other cutaneous side effects reported for this drug.
Zenas Z N Yiu, Faisal R. Ali, Christopher Em Griffiths (2015). Paradoxical exacerbation of chronic plaque psoriasis by sorafenib. , 41(4), DOI: https://doi.org/10.1111/ced.12788.
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Type
Article
Year
2015
Authors
3
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1111/ced.12788
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