Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis

(Cell Metabolism 33, 411–423.e1–e4; February 2, 2021) In the originally published version of this article, an earlier draft of Figure 5 was mistakenly included. This has now been replaced with the final version, which includes data generated during the revision process. Updated figure panels now include bacterial killing of Staphylococcus aureus (SH1000) (Figure 5B), baseline ATP levels (Figure 5D), glycolytic response to SH1000 (Figures 5E and 5F), and tracing of U-13C glutamine into F1,6BP (Figure 5R). Figure 5G has been removed and replaced by 5E; 5L has been removed and replaced by 5D. The remaining panels have been renumbered in line with the figure legend and Results text. The figure legend in the originally published article is correct and corresponds to the updated figure. This error does not affect the data and conclusions of the paper. The authors sincerely apologize for any confusion that this error may have caused.Figure 5. COPD Peripheral Blood Neutrophils Are Unable to Regulate Their Glycogen Synthesis, Resulting in Diminished Intracellular Glycogen Stores, Defective Bacterial Killing, and Survival (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and GlycogenesisSadiku et al.Cell MetabolismDecember 10, 2020In BriefNeutrophils are required to meet their energy demands at inflamed sites where nutrients may be limited. Sadiku et al. provide evidence of a specialized metabolism that enables neutrophils to utilize glycogen cycling for energy production. This is essential for neutrophil function and survival, and dysregulation is associated with chronic disease states. Full-Text PDF Open Access