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Get Free AccessIn mice given injections of a liver carcinogen (DEN), expression of NOX1 by macrophages promotes hepatic tumorigenesis by inducing the production of inflammatory cytokines. We propose that upon liver injury, damage-associated molecular patterns released from dying hepatocytes activate liver macrophages to produce cytokines that promote tumor development. Strategies to block NOX1 or these cytokines might be developed to slow hepatocellular carcinoma progression.
Shuang Liang, Hsiao-Yen Ma, Zhenyu Zhong, Debanjan Dhar, Xiao Liu, Jun Xu, Yukinori Koyama, Takahiro Nishio, Daniel Karin, Gabriel Karin, Ryan McCubbin, Cuili Zhang, Ronglin Hu, Guizhi Yang, Li Chen, Souradipta Ganguly, Tian Lan, Michael Karin, Tatiana Kisseleva, David A. Brenner (2018). NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. , 156(4), DOI: https://doi.org/10.1053/j.gastro.2018.11.019.
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Type
Article
Year
2018
Authors
20
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1053/j.gastro.2018.11.019
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