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  5. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice

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Article
en
2018

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice

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0 Files

en
2018
Vol 156 (4)
Vol. 156
DOI: 10.1053/j.gastro.2018.11.019

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Michael Karin
Michael Karin

University of California, San Diego

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Shuang Liang
Hsiao-Yen Ma
Zhenyu Zhong
+17 more

Abstract

In mice given injections of a liver carcinogen (DEN), expression of NOX1 by macrophages promotes hepatic tumorigenesis by inducing the production of inflammatory cytokines. We propose that upon liver injury, damage-associated molecular patterns released from dying hepatocytes activate liver macrophages to produce cytokines that promote tumor development. Strategies to block NOX1 or these cytokines might be developed to slow hepatocellular carcinoma progression.

How to cite this publication

Shuang Liang, Hsiao-Yen Ma, Zhenyu Zhong, Debanjan Dhar, Xiao Liu, Jun Xu, Yukinori Koyama, Takahiro Nishio, Daniel Karin, Gabriel Karin, Ryan McCubbin, Cuili Zhang, Ronglin Hu, Guizhi Yang, Li Chen, Souradipta Ganguly, Tian Lan, Michael Karin, Tatiana Kisseleva, David A. Brenner (2018). NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. , 156(4), DOI: https://doi.org/10.1053/j.gastro.2018.11.019.

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Publication Details

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Article

Year

2018

Authors

20

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0

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0

Language

en

DOI

https://doi.org/10.1053/j.gastro.2018.11.019

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