Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

How to cite this publication

Meian He, Min Xu, Ben Zhang, Jun Liang, Peng Chen, Jong‐Young Lee, Todd A. Johnson, Huaixing Li, Xiaobo Yang, Juncheng Dai, Liming Liang, Lixuan Gui, Qibin Qi, Jinyan Huang, Yanping Li, Linda S. Adair, Tin Aung, Qiuyin Cai, Ching‐Yu Cheng, Myeong‐Chan Cho, Yoon Shin Cho, Minjie Chu, Bin Cui, Yu-Tang Gao, Min Jin Go, Dongfeng Gu, Weiqiong Gu, Huan Guo, Yongchen Hao, Jie Hong, Zhibin Hu, Yanling Hu, Jianfeng Huang, Joo‐Yeon Hwang, M. Kamran Ikram, Guangfu Jin, Daehee Kang, Chiea Chuen Khor, Bong‐Jo Kim, Hung Tae Kim, Michiaki Kubo, Jeannette Lee, Juyoung Lee, Sang Lee, Ruoying Li, Jun Li, Jianjun Liu, Jirong Long, Wei Lü, Xiangfeng Lu, Xiaoping Miao, Yukinori Okada, Rick Twee‐Hee Ong, Gaokun Qiu, Mark Seielstad, Xueling Sim, Huai‐Dong Song, Fumihiko Takeuchi, Toshihiro Tanaka, Phil R. Taylor, Laiyuan Wang, Weiqing Wang, Yiqin Wang, Chen Wu, Ying Wu, Yong-Bing Xiang, Ken Yamamoto, Handong Yang, Ming Liao, Mitsuhiro Yokota, Terri L. Young, Xiaomin Zhang, Norihiro Kato, Qing K. Wang, Wei Zheng, Frank B Hu, Dongxin Lin, Hongbing Shen, Yik Ying Teo, Zengnan Mo, Tien Yin Wong, Xu Lin, Karen L. Mohlke, Guang Ning, Tatsuhiko Tsunoda, Bok-Ghee Han, Xiao‐Ou Shu, E Shyong Tai, Tangchun Wu, Lu Qi (2014). Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. , 24(6), DOI: https://doi.org/10.1093/hmg/ddu583.

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Publication Details

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Article

Year

2014

Authors

90

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.1093/hmg/ddu583

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