0 Datasets
0 Files
Get instant academic access to this publication’s datasets.
Yes. After verification, you can browse and download datasets at no cost. Some premium assets may require author approval.
Files are stored on encrypted storage. Access is restricted to verified users and all downloads are logged.
Yes, message the author after sign-up to request supplementary files or replication code.
Join 50,000+ researchers worldwide. Get instant access to peer-reviewed datasets, advanced analytics, and global collaboration tools.
✓ Immediate verification • ✓ Free institutional access • ✓ Global collaborationJoin our academic network to download verified datasets and collaborate with researchers worldwide.
Get Free AccessRecent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
Wanqing Wen, Wei Zheng, Yukinori Okada, Fumihiko Takeuchi, Yasuharu Tabara, Joo-Yeon Hwang, Naoyuki Takashima, Yoon Shin Cho, Rick TH Ong, Ling Lu, Chien-Hsiun Chen, Aihua Tan, Treva Rice, Linda S. Adair, Lixuan Gui, Matthew Allison, Wen‐Jane Lee, Qiuyin Cai, Minoru Isomura, Satoshi Umemura, Young Jin Kim, Mark Seielstad, James E. Hixson, Yong‐Bing Xiang, Masato Isono, Bong-Jo Kim, Xueling Sim, Wei Lü, Toru Nabika, Juyoung Lee, Wei‐Yen Lim, Yu‐Tang Gao, Ryoichi Takayanagi, Daehee Kang, Tien Yin Wong, Chao A. Hsiung, I‐Chien Wu, Jyh‐Ming Jimmy Juang, Jiajun Shi, Bo Youl Choi, Tin Aung, Frank B Hu, Mi Kyung Kim, Wei Yen Lim, Tzung-Dao Wang, Min‐Ho Shin, Jeannette Lee, Bu‐Tian Ji, Young Hoon Lee, Terri L. Young, Dong Hoon Shin, Byung‐Yeol Chun, Myeong‐Chan Cho, Bok‐Ghee Han, Chii‐Min Hwu, Themistocles L. Assimes, Devin Absher, Xiaofei Yan, Eric H. Kim, Jane Z. Kuo, Soonil Kwon, Kent D. Taylor, Yii‐Der I. Chen, Jerome I. Rotter, Lu Qi, Dingliang Zhu, Tangchun Wu, Karen L. Mohlke, Dongfeng Gu, Rajkumar Dorajoo, Huaixing Li, Fuu‐Jen Tsai, Xiaobo Yang, Jiang He, Ying Wu, Meian He, Yi Zhang, Jun Liang, Xiuqing Guo, Wayne Huey‐Herng Sheu, Ryan Delahanty, Xingyi Guo, Michiaki Kubo, Ken Yamamoto, Takayoshi Ohkubo, Min Jin Go, Jianjun Liu, Wei Gan, Ching‐Chu Chen, Yong Gao, Shengxu Li, Sang Lee, Chen Wu, Xueya Zhou, Huai‐Dong Song, Jie Yao, I‐Te Lee, Jirong Long, Tatsuhiko Tsunoda, Koichi Akiyama (2014). Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. , 23(20), DOI: https://doi.org/10.1093/hmg/ddu248.
Datasets shared by verified academics with rich metadata and previews.
Authors choose access levels; downloads are logged for transparency.
Students and faculty get instant access after verification.
Type
Article
Year
2014
Authors
100
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1093/hmg/ddu248
Access datasets from 50,000+ researchers worldwide with institutional verification.
Get Free Access
