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Get Free AccessMIF regulates HIF-1 activity in a p53-dependent manner. In addition to MIF's potent effects on the immune system, MIF is linked to fundamental processes conferring cell proliferation, cell survival, angiogenesis, and tumor invasiveness. This functional interdependence between MIF and HIF-1alpha protein stabilization and transactivation activity provide a molecular mechanism for promotion of tumorigenesis by MIF.
Seiko Oda, Tomoyuki Oda, Kenichiro Nishi, Satoshi Takabuchi, Takuhiko Wakamatsu, Tomoharu Tanaka, Takehiko Adachi, Kazuhiko Fukuda, Gregg L. Friedman, Kiichi Hirota (2008). Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner. , 3(5), DOI: https://doi.org/10.1371/journal.pone.0002215.
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Type
Article
Year
2008
Authors
10
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1371/journal.pone.0002215
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