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Get Free AccessObjective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
J. Muscat, Lorenzo Richiardi, Dana Mateș, G. Cadoni, Hermann Brenner, Raquel Ajub Moysés, Παγώνα Λάγιου, P. Boffetta, M. Hashibe, José P. Zevallos, Eva Negri, Jolanta Lissowska, Philip Lazarus, G. Li, L. Fernández, Ariana Znaor, David I. Conway, R. Herrero, Marta Vilensky, Danièle Luce, Neil D. Gross, E. Fabianova, E.M. Sturgis, M. Gillison, Silvia Franceschi, Carlo La Vecchia, Simone Benhamou, Alexander W. Daudt, Oxana Shangina, Diego Serraino, Gwenn Menvielle, D.M. Winn, Shih‐Chang Chuang, Gary J. Macfarlane, W. Garavello, Tatiana Natasha Toporcov, C. Chen, S. Boccia, Gypsyamber D’Souza, Yu Gao, V. Wunsch-Filho, K. Kelsey, María Paula Curado, Wolfgang Ahrens, K. Moysich, T. Zheng, Kristina Kjærheim, Ivana Holcátová, Keitaro Matsuo, Claire M. Healy, Rosalina Jorge Koifman, Cristina Canova, Zuo‐Feng Zhang, E. Smith, Beata Świątkowska, Y.-C.A. Lee, F. Levi, Francesca Bravi, Loredana Radoï, Jerry Polesel, the INHANCE Consortium investigators, M. McClean, Peter Thomson, T.L. Vaughan, Stimson Schantz, Tamás Pándics, Mark P. Purdue, H. Ramroth, Paul M. Brennan, RP Hayes, H. Morgenstern, Antonio Agudo, Luigino Dal Maso, S.M. Schwartz, Valeria Edefonti, Ana B Clara B Menezes, Monica Ferraroni, A.F. Olshan (2024). Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. , DOI: https://doi.org/10.17615/wnwc-8434.
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Type
Article
Year
2024
Authors
78
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.17615/wnwc-8434
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