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Get Free AccessOxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly on cytokines. Here, using a standardized whole-blood stimulation system, we characterized the oxylipin-driven inflammatory responses to various stimuli and their relationships with cytokine responses. We performed a pilot study in 25 healthy individuals using 6 different stimuli: 2 bacterial stimuli (LPS and live BCG), 2 viral stimuli (vaccine-grade poly I:C and live H1N1 attenuated influenza), an enterotoxin superantigen and a Null control. All stimuli induced a strong production of oxylipins but most importantly, bacterial, viral, and T cell immune responses show distinct oxylipin signatures. Integration of the oxylipin and cytokine responses for each condition revealed new immune networks improving our understanding of inflammation regulation. Finally, the oxylipin responses and oxylipin-cytokine networks were compared in patients with active tuberculosis or with latent infection. This revealed different responses to BCG but not LPS stimulation highlighting new regulatory pathways for further investigations.
Étienne Villain, Aurélie Chanson, Malwina Mainka, Nadja Kampschulte, Pauline Le Faouder, Justine Bertrand‐Michel, Marion Brandolini-Bunlon, Bruno Charbit, Munyaradzi Musvosvi, Nicole Bilek, Thomas J. Scriba, Lluís Quintana‐Murci, Nils Helge Schebb, Darragh Duffy, Cécile Gladine, Laurent Abel, Andrés Alcover, Hugues Aschard, Philippe Bousso, Nollaig M. Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf‐Bensussan, Ana Cumano, Christophe d’Enfert, Ludovic Deriano, Marie‐Agnès Dillies, James P. Di Santo, Gérard Eberl, Jost Enninga, Jacques Fellay, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Eric Camerer, Hugo Mouquet, Cliona OʼFarrelly, Étienne Patin, Sandra Pellegrini, Antonio Rausell, Frédéric Rieux‐Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie‐Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert, Darragh Duffy, Lluís Quintana‐Murci (2023). Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks. , 26(8), DOI: https://doi.org/10.1016/j.isci.2023.107422.
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Type
Article
Year
2023
Authors
58
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.isci.2023.107422
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