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Get Free AccessThe hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.
Unn K. Haukvik, Tiril P. Gurholt, Stener Nerland, Torbjørn Elvsåshagen, Theophilus N. Akudjedu, Martin Alda, Dag Alnæs, Sílvia Alonso-Lana, Jochen Bauer, Bernhard T. Baune, Francesco Benedetti, Michael Berk, Francesco Bettella, Erlend Bøen, Caterina del Mar Bonnín, Paolo Brambilla, Erick J. Canales‐Rodríguez, Dara M. Cannon, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Díaz‐Zuluaga, Theo G. M. van Erp, Mar Fatjó‐Vilas, Sonya Foley, Katharina Förster, Janice M. Fullerton, José Manuel Goikolea, Dominik Grotegerd, Oliver Gruber, Bartholomeus C. M. Haarman, Beathe Haatveit, Tomáš Hájek, Brian Hallahan, Mathew A. Harris, Emma L. Hawkins, Fleur M. Howells, Carina Hülsmann, Neda Jahanshad, Kjetil Nordbø Jørgensen, Tilo Kircher, Bernd Krämer, Axel Krug, Rayus Kuplicki, Trine Vik Lagerberg, T. Lancaster, Rhoshel Lenroot, Vera Lonning, Carlos López‐Jaramillo, Ulrik Fredrik Malt, Colm McDonald, Andrew M. McIntosh, Genevieve McPhilemy, Dennis van der Meer, Ingrid Melle, Elisa Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadić, Viola Oertel, Lucio Oldani, Nils Opel, Maria Concepción García Otaduy, Bronwyn J. Overs, Julian A. Pineda‐Zapata, Edith Pomarol‐Clotet, Joaquim Raduà, Lisa Rauer, Ronny Redlich, Jonathan Repple, Maria M. Rive, Gloria Roberts, Henricus G. Ruhé, Lauren E. Salminen, Raymond Salvador, Salvador Sarró, Jonathan Savitz, Aart H. Schene, Kang Sim, Márcio Gerhardt Soeiro‐de‐Souza, Michael Stäblein, Dan Joseph Stein, Frederike Stein, Christian K. Tamnes, Henk Temmingh, Sophia I. Thomopoulos, Dick J. Veltman, Eduard Vieta, Lena Waltemate, Lars T. Westlye, Heather C. Whalley, Philipp G. Sämann, Paul M. Thompson, Christopher R. K. Ching, Ole A. Andreassen, Ingrid Agartz (2020). In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through <scp>Meta‐Analysis</scp> Bipolar Disorder Working Group. , 43(1), DOI: https://doi.org/10.1002/hbm.25249.
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Type
Article
Year
2020
Authors
97
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/hbm.25249
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