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Get Free AccessEinleitung: Der angiogene Wachstumsfaktor Placental growth factor (PlGF), ein Homolog von VEGF, stimuliert über VEGF Rezeptor-1 die Proliferation von Endothelzellen und die Aktivität angiogener Makrophagen und trägt somit zur Tumorangiogenese bei. Wir demonstrierten jüngst das therapeutische Potential eines anti-PlGF Antikörpers (αPlGF), Tumorwachstum und Metastasierung effizient zu inhibieren.
C. Fischer, Maria Grazia Mazzone, Bart Jonckx, Serena Zacchigna, Katharina Detjen, JM Stassen, Désiré Collen, M Dewerchin, Bertram Wiedenmann, Peter Carmeliet (2008). In vitro und in vivo zytostatische Effekte von anti-PlGF via Inhibition der VEGFR-1 abhängigen MAPK und AKT Signalwege in Tumorzellen. , 46(09), DOI: https://doi.org/10.1055/s-0028-1089482.
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Type
Article
Year
2008
Authors
10
Datasets
0
Total Files
0
Language
de
DOI
https://doi.org/10.1055/s-0028-1089482
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