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Get Free AccessOur data identified HIF-1α as a regulator of CD44 that increased the number of CD44 molecules and the percentage of CD44 positive cells expressing variant exons v6 and v7/8 in breast cancer cells under hypoxic conditions. Data from these cell studies were further supported by in vivo observations that hypoxic tumor regions contained cells with a higher concentration of CD44 expression.
Balaji Krishnamachary, Marie‐France Penet, Sridhar Nimmagadda, Yelena Mironchik, Venu Raman, Meiyappan Solaiyappan, Gregg L. Friedman, Martin G. Pomper, Zaver M. Bhujwalla (2012). Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer. , 7(8), DOI: https://doi.org/10.1371/journal.pone.0044078.
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Type
Article
Year
2012
Authors
9
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1371/journal.pone.0044078
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