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Get Free AccessThe vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.
Sergio Rey, Gregg L. Friedman (2010). Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. , 86(2), DOI: https://doi.org/10.1093/cvr/cvq045.
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Type
Article
Year
2010
Authors
2
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1093/cvr/cvq045
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