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Get Free AccessRecent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity.
Liwei Zhao, Peng Liu, Oliver Kepp, Guido Guido Kroemer (2025). How macrophages use extracellular calreticulin to chase their prey. , 14(1), DOI: https://doi.org/10.1080/2162402x.2025.2533494.
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Type
Article
Year
2025
Authors
4
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1080/2162402x.2025.2533494
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